Selected reading of Reflections; or Sentences and Moral Maxims

Course reading ebook adapted by Ian D. Dunkle from Project Gutenberg's Reflections, by Francois Duc De La Rochefoucauld, translated by J.W. Willis Bund and J. Hain Friswell.: https://www.gutenberg.org/ebooks/9105In a distinctive and polished series of short aphorisms, La Rochefoucauld explores the oddities of human nature and how they affect our use of moral categories to understand the behavior of ourselves and others

Maritime pine PpMYB8 directly co-regulates secondary cell wall architecture and the associated Phe-biosynthesis pathway

Plants rely on the biosynthesis of L-Phenylalanine as building block for the synthesis of proteins but also as precursor for a tremendous range of plant-derived compounds essential for its grown, development and defense. Polymerization of secondary cell wall in trees involves the massive biosynthesis, among others, of the Phe-derived compound lignin. Thus, these plants require an accurate metabolic coordination between Phe and lignin biosynthesis to ensure its normal development. We have here identified that the pine arogenate dehydratase, whose enzyme activity limits the biosynthesis of Phe in plants, is transcriptionally regulated through direct interaction with PpMyb8. We have also shown that this transcription factor is directly involve in secondary cell wall biogenesis and cell death processes. Together these results indicate that a single transcription factor coordinates lignin accumulation and the proper biosynthesis of its essential precursor L-Phe.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Sport and History: Continuity and Change. Local Stories to Explain Global History

A collection of quality papers selected from those presented at the 2021 joint Congress of the European Committee of Sports History (CESH) and the International Society for the History of Physical Education and Sport (ISHPES) in Lisbon, Portugal, has been gathered to bring an array of contemporary perspectives on sports history

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus

Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against acute uncomplicated influenza. Results: We report the activity of seventeen thiazolide analogs against A/PuertoRico/8/1934(H1N1), a laboratory-adapted strain of the H1N1 subtype of IAV, in a cell culture-based assay. A total of eight analogs showed IC50s in the range of 0.14–5.0 μM. Additionally a quantitative structure–property relationship study showed high correlation between experimental and predicted activity based on a molecular descriptor set. Conclusion: A range of thiazolides show useful activity against an H1N1 strain of IAV. Further evaluation of these molecules as potential new small molecule therapies is justified

La Responsabilidad Social Universitaria en la Universidad Católica de Córdoba: una opción de gestión. Acciones emprendidas durante el período 2005 al 2007

Fil: Velasco, Luis Rafael. Universidad Católica de Córdoba; ArgentinaFil: Gargantini, Daniela Mariana. Universidad Católica de Córdoba; ArgentinaFil: Morello, Enzo Gustavo. Universidad Católica de Córdoba; Argentin

Optimized V-shape design of GaN nanodiodes for the generation of Gunn oscillations

In this work, recent advances in the design of GaN planar Gunn diodes with asymmetric shape, socalled self-switching diodes, are presented. A particular geometry for the nanodiode is proposed, referred as V-shape, where the width of the channel is intentionally increased as approaching the anode. This design, which reduces the effect of the surface-charges at the anode side, is the most favourable one for the onset of Gunn oscillations, which emerge at lower current levels and with lower threshold voltages as compared to the standard square geometry, thus enhancing the power efficiency of the self-switching diode as sub-millimeter wave emitters

Time-domain Monte Carlo simulation of GaN planar Gunn nanodiodes in resonant circuits

In this work we present a theoretical study based on time-domain Monte Carlo (MC) simulations of GaN-based Self-Switching Diodes (SSDs) oriented to the experimental achievement and control of the sub-THz Gunn-oscillations potentially provided by these devices. With this aim, an analysis of the frequency performance of SSDs connected to a resonant RLC parallel circuit, is reported here. V-shaped SSDs have been found to be more efficient, in terms of the DC to AC conversion efficiency η, than similar square-shape ones. Indeed, a value of η of at least 0.80%, can be achieved with appropriate RLC elements, even when considering heating effects. When the influence of parasitic elements such as the crosstalk capacitance Ctalk is evaluated, MC simulations have shown that the resonant circuit must contain a capacitance C higher than Ctalk in order to obtain experimentally useful values of η. This condition can be reached by integrating a sufficiently high number N of parallel SSDs in the fabricated devices. MC simulations have also shown that when several diodes are fabricated in parallel the oscillations of all the SSDs are not synchronized, but this problem is solved by the attachment of a resonant RLC tank